Signs and symptoms commonly seen in COVID-19 in newborns, children, and adolescents and pediatric subjects

The recent findings reported that the most frequent coronavirus disease 2019 (COVID-19) clinical course in pediatric subjects ranged from mild to moderate form in with nonspecific symptoms such as fever, cough, dyspnea, fatigue, muscle pain, headache, and nasal congestion. On the contrary, a lower frequency of severe COVID-19 forms was reported, including refractory metabolic acidosis, coagulation disorders, tachypnea, severe pneumonia, and septic shock. Recent literature is associated with the COVID-19 pediatric subject to the acute multisystem inflammatory syndrome (MIS-C) with abdominal symptoms and left ventricular systolic dysfunction. The recent findings seem to support that the unvaccinated and comorbid children could present more severe clinical forms. Few data of COVID-19 hospitalization in pediatric intensive care unit (PICU) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in schools were reported during the first wave. The main reasons could be correlated to the early school's closure, while the swabs were destined more frequently to adult symptomatic subjects. The pandemic state generated rise in psychological disorders, anxiety, and depression more frequently during the first year of the disease spread, with a higher prevalence in older adolescents. © 2023 Elsevier Inc. All rights reserved.

Augmented and virtual reality as training tool for maxillofacial surgeons and neurosurgeons: is it the future?

Recent biotechnological advances, including three-dimensional microscopy and endoscopy, virtual reality, surgical simulation, surgical robotics, and advanced neuroimaging, have moulded the surgeon-computer relationship. For developing neurosurgeons and maxillofacial surgeons, such tools can reduce the learning curve, improve conceptual understanding of complex anatomy, and enhance visuospatial skills. However, current clinical trials in dental virtual reality must still be experimental.

Surgical multidisciplinarity for precision medicine: the challenge for the future

Multidisciplinary care has been shown to improve patient outcomes, and interprofessional collaboration has been shown to improve one's medical knowledge. Multidisciplinary interventions in the field of surgery are designed to address a specific problem occurring in a particular patient population and/or within the context of an individual hospital system. The importance of multidisciplinarity and interdisciplinarity at all levels, including clinical oncology, craniofacial trauma, and brain abscess caused by dental peri-implantitis, is well established. The challenge for future research is to further develop and validate medical team performance assessment instruments;this will help improve medical and surgical team training efforts and aid the design of clinical work systems supporting effective teamwork and safe patient care.

Neurosurgical and craniofacial surgery during the Covid-19 pandemic

The pandemic of coronavirus disease (COVID-19) resulted in an unprecedented global public health crisis and impacted all spheres of life, including all economic activity, travel, governance, education, surgery and, of course, healthcare. Neurosurgery, dentistry, and maxillofacial surgery are also not spared. Surgeons operating near the aerodigestive tract are at particularly high risk of being infected, and consequently, they shifted their practices toward more protective personal protective equipment. In the present digital era, surgeons use more and more web, teleconsulting, and virtual reality to effectively communicate with patients and their relatives on treatment strategies and appointments for surgical works. The COVID-19 situation also provides a novel opportunity to learn, update our knowledge, and update ourselves such that we continue to save lives. In conclusion, it seems appropriate to request that every healthcare institution receives well-researched and documented protocols for dealing with future inevitable global pandemics. © by BIOLIFE, s.a.s.

Periodontal disease and clinical association with COVID-19 infection

SARS-CoV-2 infection can cause long-standing damage to the immune system characterized by increased inflammatory cytokine activation. Maintaining periodontal health may reduce host susceptibility to COVID-19 and prevent COVID-19 aggravation in infected patients. There is sufficient evidence in the literature to warrant an association between the presence of PDs and the development and course of respiratory illnesses. Optimum oral health, maintaining good systemic health, and elimination of smoking habits may be beneficial for the prevention and management of COVID-19 infections. Future studies on the periodontal status of patients with COVID-19, including from mild to severe forms, could allow the opportune identification of people at risk of severe illness and generate relevant recommendations. The connection, if any, between the oral microbiome and COVID-19 complications is urgently required to establish the importance of oral hygiene and pre-existing oral disease in the severity and mortality risk of COVID-19.

Apulian regional network for the integration of thrombosis centers and social health districts

Background: the use of portable coagulometers and the development of telemedicine have enabled the integration between the territory and Thrombosis Centers, leading to the emergence of Decentralized Specialist Assistance. The clinical advantages of DSA are: reduction of complications, reduction of the workload of the professionals involved, improvement of patients' quality of life and reduction of OAT management costs. In addition, the DSA allows specialists to create a network linking Thrombosis Centers, blood drawing area, and patients. During the SARS-COV-2 pandemic in the ASL BARI and in the A.O.U Policlinico of Bari in collaboration with the E-Health Area of AReSS Puglia and, Werfen, this model was tested.Methods: 200 patients aged 42 to 96 years managed by the Parma-GTS (Global therapy solution) software Instrumentation Laboratory , were enrolled. For each patient, PT was performed using analytical systems in use in the laboratory (ACL TOP 500 CTS with HemosIL RecombiPlastinTin 2GIL and SYSMEX CS 51000 SYSTEM-SIEMENS with Innovin, Dade) and by digitopuncture with microINR coagulometer ( Instrumentation Laboratory). Patients received an electronic report on various devices (PC, tablet, smartphone) ,after expressing informed consent, through homeTAO an optional service integrated in PARMA GTS. Statistical analysis was performed by linear regression and the Bland Altman method. All patients were given an evaluation questionnaire about the reception, the improvement in the quality of life and the simplicity of capillary sampling compared to venous blood sampling as well as the use of homeTAO.Results: The data analysis showed the concordance of the results of the microINR systems with the systems in use in the laboratory in accordance with ISO 17593: 2007. The Pearson's coefficient calculated for all centers is 0.941. In addition, 96% of patients expressed satisfaction with the services offered.Conclusions: the trial demonstrated the possibility of integrating District and thrombosis centres using a single OAT software. The connection of the microINR to the management software allows immediate availability of the analytical data and the homeTAO service allows the domiciliation of the report.

Compliance of children with removable functional appliance with microchip integrated during covid-19 pandemic: a systematic review.

Treatments with removable appliances are widely used in Europe to correct dento-skeletal dysgnatia in the growth phase that is a period of poor cooperation of the patients. Adherence to the wear-time prescription is often not achieved and it represent the main argument against the use of removable devices. Suspected non-compliant behavior with the wear time prescription is often the subject of medico-legal disputes, which can deteriorate doctor-patient relationship. The use of microchips allows to document objectively and clarify the patient's behavior. To conduct a systematic review of the orthodontic literature to identify the factors associated with compliance in orthodontic treatment. We conduct a systematic review that aimed to identity the factors associate with compliance in orthodontic treatment. The main purpose was to assess the objective levels of time of use of the removable appliances and the self-reported levels. A literature search was conducted by the electronic databases PubMed and Cochrane Library. The following search terms were used: compliance functional removable orthodontic appliance. Randomized and nonrandomized controlled trials, prospective cohort studies, case series, qualitative and mixed-methods studies objectively assessing compliance levels were included in the study. A total of 94 articles were identified by PubMed and 14 articles by Cochrane. The papers selected were included for the qualitative analysis and categorized according to the subjects age, the clinical appliance, compliance factors, wear time and monitoring. Removable appliances are an important part of orthodontic treatment, used in growth phase of the patient. Collaboration with removable functional devices determines success / failure in treatment.

The integumentary system and its microbiota between health and disease.

The aim of the present investigation was to evaluate the essential physiological functions of the skin microbiota in human health and diseases. The main characteristics of the normal microbiota in the different anatomical sites have been reported in relation to the main factors, such as the effect of age, on its composition and stability for the eubiosis condition. Moreover, the present overview analyzed the functions and composition and the correct functionality of the skin microbiota in the light of current knowledge. According to several evidence is important preserving the eubiosis of the commensal microbes of the microecosystem (symbiotic and pathogenic), and probiotics are able to counteract the conditions of dysbiosis. Also, it has been shown that there is a crosstalk between gut and skin microbiota that affects human health and is still being studied, and its relationship to the current pandemic SARS-CoV-2.

SARS-CoV-2 Disease through Viral Genomic and Receptor Implications: An Overview of Diagnostic and Immunology Breakthroughs

The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which is believed to have originated in China towards the end of November 2019, has now spread across the globe, causing a pandemic in 192 countries. The World Health Organization has called it the SARS-CoV-2 pandemic. Rapid dissemination of the virus occurs mainly through the saliva (Flugge's droplets) and aerosol, together with nasal and lachrymal passages. The literature associated with the recent advancement in terms of rapid diagnostics and SARS-CoV-2 vaccines has thoroughly studied the role of ACE2 receptors and Furin, as well as viral agent access into the host cell and its significant persistence at the level of the oral mucosa, which represents the main access to the virus. The purpose of this review was to underline the processes of SARS-CoV-2 infection mechanisms and novel breakthroughs in diagnostics and vaccines. Different technologies, such as the RT-PCR molecular test and the antigenic test, have been developed to identify subjects affected by the SARS-CoV-2 in order to improve the tracking of infection geographical diffusion. Novel rapid and highly sensitive diagnostic tests has been proposed for the detection of SARS-CoV-2 to improve the screening capability of suspected contagions. The strengthening of the vaccination campaign represents the most effective means to combat the SARS-CoV-2 infection and prevent severe manifestations of the virus-different classes of vaccines have been developed for this purpose. Further attention on the novel SARS-CoV-2 variant is necessary in order to verify the protection efficacy and virulence reduction of the infective agent in the recent vaccine campaign.